In a special collection of articles published beginning 1 July 2005, Science Magazine and its online companion sites celebrate the journal's 125th anniversary with a look forward -- at the most compelling puzzles and questions facing scientists today. A special, free news feature in Science explores 125 big questions that face scientific inquiry over the next quarter-century; accompanying the feature are several online extras including a reader's forum on the big questions. The Signal Transduction Knowledge Environment highlights some classic Science papers that have influenced the study of cell signaling. The Science of Aging Knowledge Environment looks at several important questions confronting researchers on aging. And Science's Next Wave introduces us to four young scientists building their careers grappling with some of the very questions that Science has identified.
125th Anniversary Issue: Science Online Special Feature